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Defrol 1000IU Tablet 10pcs
Defrol 1000 IU Tablet is used for the treatment and prevention of conditions related to Vitamin D deficiency, including:
- Osteoporosis
- Hypoparathyroidism
- Rickets
- Osteomalacia
- Vitamin D Deficiency
- Pseudohypoparathyroidism
- Familial Hypophosphatemia
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✅ Description:
✔️ Dosage:
Defrol can be taken with or without food. It may be administered orally or intramuscularly (IM) as prescribed by the healthcare provider.
Adult Dosage
- Nutritional Deficiency (Vitamin D3):
- 5-10 mcg (200-400 IU) per day orally.
- Osteoporosis Prophylaxis and Treatment (>50 years):
- 800-1000 IU (20-25 mcg) daily with calcium supplements.
- May also be given as an IM injection.
- Hypoparathyroidism:
- 50,000-200,000 IU (0.625-5 mg) orally once daily with calcium supplements, or via IM injection.
Child Dosage
- Nutritional Supplementation:
- 0-12 months: 400 IU (10 mcg) once daily.
- 1-18 years: 600 IU (15 mcg) once daily.
- Vitamin D-Resistant Rickets:
- 12,000-500,000 IU (0.3-12.5 mg) orally once daily.
- Familial Hypophosphatemia:
- 40,000-80,000 IU (1-2 mg) once daily with phosphate supplements.
- May be reduced after the growth phase is complete.
✔️ Generally well tolerated, but some side effects may include:
- Hypercalcaemia (excessive calcium) or calcium intoxication.
- Acute symptoms of hypercalcemia: Anorexia, headache, dry mouth, nausea, vomiting, abdominal pain, or constipation.
✔️ Colecalciferol should not be used in:
- Patients with hypercalcemia (high blood calcium levels).
- Those with known hypersensitivity to Colecalciferol or related medications.
- Vitamin D toxicity.
✔️ Mode of Action:
Colecalciferol is a fat-soluble sterol essential for calcium and phosphate homeostasis, as well as bone mineralization. It enhances calcium absorption from the gastrointestinal tract and stimulates bone formation, promoting overall bone health.
✔️ Interactions
- Increased risk of hypercalcaemia when used with thiazide diuretics, calcium, or phosphate.
- Antiepileptic medications (e.g., carbamazepine, phenobarbitone, phenytoin, primidone) may require higher doses of vitamin D.
- Rifampicin and isoniazid may reduce vitamin D efficacy.
- Corticosteroids may counteract Vitamin D effects.
- Digoxin or any cardiac glycosides may have interactions.
- Reduced absorption when taken with cholestyramine, colestipol, mineral oil, or orlistat
✔️ Use with caution in individuals with:
- High blood calcium or phosphorus levels.
- Heart problems.
- Kidney disease.
- Ensure adequate intake of calcium and magnesium alongside Vitamin D.
- Lactation: Vitamin D is distributed into breast milk; use cautiously during breastfeeding.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
